Both teams have already secured a top-two finish in Group C
Joachim Low’s side will secure their place in Russia next summer if they avoid defeat to Northern Ireland on Thursday evening.
Germany currently sit top of the group with 24 points, while Northern Ireland are 5 points behind them.
Aaron Hughes withdrew from the Northern Ireland squad after picking up a calf strain and Craig Cathcart will also miss out.
Meanwhile, Germany will be without a number of recognisable through injury or a lack of fitness, with Manuel Neuer, Marco Reus, Mario Gomez, Mario Gotze, Mesut Ozil and Sami Khedira all not included in the squad.
Germany are unbeaten in their last 17 matches in all competitions, while Northern Ireland have won their last five internationals, their longest ever winning run.
Here are the potential lineups:
Germany: Ter Stegen; Mustafi, Hummels, Boateng; Kimmich, Kroos, Rudy, Draxler, Sane; Muller, Stindl.