Holders Barcelona will face Arsenal in the last 16 when they resume their quest to become the first team to successfully defend the Champions League in February.

The La Liga champions have a strong record against Arsene Wenger’s team since defeating the Londoners in the 2006 decider in Paris.

Barcelona knocked Arsenal out in back-to-back years in 2010 and 2011 and Luis Enrique’s team will fancy their chances once more against a side that has already been beaten by Dinamo Zagreb and Olympiacos in the competition this season.

Last season’s beaten finalists Juventus were handed a tough task having failed to top their group this time around, they will meet Pep Guardiola’s Bayern Munich.

Chelsea’s reward for winning Group G is a clash with runaway Ligue 1 leaders Paris St Germain.

Real Madrid got the better of PSG in Group A and they will face a Roma side that emerged behind Barcelona despite winning just one of their six games in the group stage.

Madrid’s city rivals Atletico were paired with PSV Eindhoven while Wolfsburg will feel they have been handsomely rewarded for denying Manchester United a spot in the last 16 as they meet Gent in the first knockout round.

Manchester City were pitted against Dynamo Kiev, who came through Group G as runners-up to Chelsea having conceded just four goals in six games.

The remaining tie will see Benfica taking on Zenit St Petersburg when the Champions League resumes on February 16.

Barcelona are 3.25 to retain the Champions League this season while Guardiola is 3.50 to bring European success to Bayern in what could be his final season in charge of the Bundesliga club.

Arsenal are 34.00 to land a first ever Champions League trophy this season.