Wales boss Ryan Giggs will be without midfielder Aaron Ramsey for the UEFA Nations League match on Tuesday against the Republic of Ireland due to family reasons.
The Arsenal star captained Wales in the second half of Thursday’s friendly defeat to Spain but he will now return to London ahead of the Gunners’ next Premier League contest.
Wales come into the game on the back of a 4-1 defeat to Spain and they will also be without Gareth Bale.
The Real Madrid star has returned to Spain due to a groin injury and Ipswich winger Gwion Edwards was called up by Wales on Friday as cover.
Swansea City’s Daniel James has also been drafted in and left the Wales U21s squad as a result.
Wales are currently second in Group B having beaten Ireland 4-1 in their opening game before falling to a 2-0 defeat against Denmark.
Bournemouth’s David Brooks has been backed to shine in the fixture in the absence of Bale by team-mate Ben Davies. Brooks has scored in his last two matches for the Cherries and Davies has warned Ireland that he will pose a serious threat.
He told Sky Sports: “Gareth is a massive loss for any team and we’ll have to adapt but he (Brooks) is a top player.
“He has a lot of ability and talent that defenders just don’t want to come up against. We’ll have a good attacking threat in him against Ireland.”
Ireland are 2.38 favourites for the game in Dublin, with the draw 3.00, while Wales are priced at odds of 3.30.