Sergio Aguero will miss Manchester City’s crucial Champions League tussle with Roma on Wednesday night after damaging knee ligaments in Saturday’s Premier League win over Everton.

The Argentine striker limped off with tears in his eyes just a couple of minutes into the game at the Etihad Stadium and boss Manuel Pellegrini confirmed he will have to plan for the game in Italy without his chief goal scorer.

“Sergio has a problem in his knee ligament. We will see how serious it is after he has had a scan,” Pellegrini said. “It is not good news and I don’t think he will be able to play next week. He will not be with us for Roma – which is an important game.”

City need three points in the Italian capital if they are to progress to the last 16 in this season’s Champions League.

Pellegrini also has further injury worries, with captain Vincent Kompany, Stevan Jovetic and David Silva all facing a race against time in order to be fit for Wednesday night.

Despite winning only one of their five Group E games – when Aguero hit a hat-trick to see off already-qualified Bayern Munich in Manchester two weeks ago – City will make the knockouts if they defeat Roma.

Captain Francesco Totti secured a point for Roma back in September at the Etihad when he cancelled out an early penalty from Aguero.

Aguero has scored 19 goals in 21 appearances in all competitions for Man City this season and his absence presents a huge challenge for Pellegrini’s side against Roma.

Man City are 2.81 to win with Roma 2.35 and the draw 3.13.