Juventus have been dealt a double blow ahead of the second leg of their Champions League last-16 tie with Bayern Munich, as both Paulo Dybala and Claudio Marchisio have been ruled out of the tie through injury.

The teams head into Wednesday’s match at the Allianz Arena level at 2-2 from the first leg, with Dybala having scored one of the Old Lady’s goals during the clash in Turin.

The Argentina international will play no part in the second leg however, with Juventus releasing a club statement confirming the 22-year-old has suffered a calf injury in training, and he is now also a doubt for the weekend derby clash with Torino in Serie A.

The statement read: “The Argentine striker was released early from training yesterday. Diagnostic tests carried out this morning have ruled out a fracture, but shown an edema overload of the left soleus muscle.

“He therefore won’t be available for the Champions League match and his condition will be monitored daily ahead of the match on Sunday against Torino.”

Italy international Marchisio will also miss the trip to Munich with a similar injury, and he is expected to be out of action for approximately 20 days.

The statement continued: “During training yesterday Marchisio suffered a muscular problem to his left calf. Checks late last night showed a first grade soleus muscle injury and the prognosis is for 20 days.”

Massimiliano Allegri’s side have failed to win any of their last five meetings with Bayern and they are outsiders at 9.00 to end that run on Wednesday, while the German outfit are on offer at 1.36 and the draw is priced at 4.75.