AC Milan, who won the Scudetto last season, got to the last four after ousting Premier League side Tottenham Hotspurs and reigning Serie A champions Napoli.
Inter, on their part, ousted two Portuguese giants, FC Porto and Benfica, to get here.
It is expected to be a clash of the clash as the Milan giants square off at San Siro tonight.
Statistics showed that there had been 235 meetings between both sides in all competitions, out of which Inter won 87, including their last two in the league and Italian Super Cup, while AC Milan won 79. 69 matches have ended in a draw.
This is also the first time in 13 years that a team from Italy’s financial and commercial hub reached the Champions League final. Since both sides are Serie A’s sides, that is about to change.
Both clubs have between them. 10 European trophies, and they will face off on Wednesday in the first of two semifinals for European football’s top club competition.
In the domestic league, Inter Milan currently sits in fourth place in the Italian league, with 63 points, two ahead of fifth-placed AC Milan.
The last time the Milan giants played each other in the Champions League was in 2005, a quarterfinal won by Milan, whose second leg was abandoned after livid Inter fans launched a barrage of flares onto the San Siro pitch with their team way behind in the tie.
Come to team news, AC Milan manager Stefano Pioli is expected to make a late call on Rafael Leao after the Portuguese limped off the pitch against Lazio after suffering a muscle injury.
In the absence of their most influential players this season with 13 goals and 10 assists in all competitions, Pioli could give Belgian winger Alexis Saelemaekers the nod.
Domestically, AC Milan, who were dethroned as Serie A champions last week by Napoli, have had a rough run in the league with only three wins in their last 10 games.
Their focus is thus expected to be on their European run.
The last time AC Milan got into the final of the Champions League was in 2007, when they beat Liverpool 2-1 in the final held in Athens, Greece.
Inter last won their first Champions League trophy in 2010 when they beat Bayern Munich 2-0 in the final in Spain’s Madrid. They are yet to add to that since.
They are going into the showdown on a run of five straight wins and with a previously misfiring attack suddenly banging in goals.
Inzaghi’s side is going into the tie on good form. They have scored 14 goals in five games, 10 of which have been netted by Romelu Lukaku and Lautaro Martinez, both on a hot streak. They are expected to be a menace to Milan’s defense.
Inter could be without full-back Robin Gosens who is a doubt after being sidelined lately with a dislocated shoulder. But the 28-year-old could return to action after taking to his Instagram page on Monday, saying he was “back on track” and fit again “just in time for the big match on Wednesday.”