Bayern Munich captain Philipp Lahm faces around three months on the sidelines after suffering a broken ankle in training.
Lahm sustained the injury on Tuesday morning and Bayern confirmed the blow on their official Twitter feed.
The club tweeted: “Big blow for Philipp Lahm the captain has suffered a fractured ankle needs an operation and he will be out for around three months.”
Lahm, who retired from international duty with Germany following their World Cup success, has been in sensational form for the Bundesliga giants this term.
The captain has featured in his regular full-back role as well as a midfield role under coach Pep Guardiola this season and his absence will be keenly felt by Bayern.
Lahm joined a lengthy injury list at the Allianz Arena, with Thiago Alcantara, Javi Martinez, Bastian Schweinsteiger and Holger Badstuber all currently sidelined, but they are already through to the knockout stages of the Champions League having topped Group E with two games to spare, with Bayern currently 4.00 to win the tournament outright.
Bayern also enjoy a four point lead at the top of the Bundesliga table after 11 games, with Guardiola’s side currently four points clear of nearest rivals Wolfsburg.
Bayern host Hoffenheim in the Bundesliga on Saturday and they can be backed at 1.14 to take all three points and 1.03 to win the German league title, while Wolfsburg are 21.00.